Numerical study of thermal dynamics of gold nanoparticles in laser-induced hyperthermia therapy

Damage of the normal tissue is a serious concenrn in cancer treatment. Hyperthermia by laserhas been considered as a safe cancer treatments methods with lower harmful effects on normaltissues. Using nanoparticles in cancer treatment has improved laser therapy, which is based ona selective cell targeting method to localize cell damages. Metallic nanoparticles such as gold,silver, and copper have been recognized to highly interact with laser beam because of surfaceplasmon resonance phenomena. However, due to toxicity of silver and copper, gold nanoparticlehave received great interest in nanomedicine particularly as a protein denaturizing agentapplied to the targeted cells. On the other hand, interaction between laser beam and nanoparticlesdepends on laser properties and particle characteristics. In this study, we have numericallyevaluated the effects of different parameters in the laser beam and particle, to facilitate theaccurate controlling of laser-induced hyperthermia process.